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李多川
发布时间:2013-09-16 浏览次数:

 

    李多川   男,1962年12月出生。1996年毕业于中国农业大学,获理学博士学位(植物病理学专业)。现为山东农业大学教授,博士生导师,新世纪国家百千万人才工程人选,国务院政府特殊津贴获得者,中国农业微生物技术学会常务理事,植物病理学报编委,山东省农业微生物重点实验室主任。

 

    1、主要科研领域与方向

       植物病原真菌与植物互作机理;极端环境真菌(嗜热真菌、耐酸真菌、耐盐真菌)适应机制及利用。

    2、开设课程

       植物检疫学,农业植物病理学,分子植物病理学

    3、近期发表的代表性论文

       Ma YN, Han C, Chen JY, Li HY, He K, Liu AX and Li DC. 2015. Fungal cellulase is an elicitor but its enzymatic activity is not required for its elicitor activity. Molecular Plant Pathology, 15:14-26.

       Xu XX, Chen JY, Xu HJ, Li DC. 2014. Role of a major facilitator superfamily transporter in adaptation capacity of Penicillium funiculosum under extreme acidic stress. Fungal Genetics and Biology, 69:75-83.

       Haikarainen T, Frioux C, Zhnag LQ, Li DC, Papageorgiou AC. 2014. Crystal structure and biochemical characterization of a manganese superoxide dismutase from Chaetomium thermophilum. Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 1844:422-429.

       Xian H, Li J, Zhang L, Li DC. 2012. Cloning and functional analysis of a novel chitinase gene Trchi1 from Trichothecium roseum. Biotechnol Lett. 34:1921-1928.

       Wang F, Li AN, Dai DM, Xu XX, Li DC. 2013. A new halotolerant species of Alternaria from Qinghai-Tibet Plateau, China. Mycotaxon, 123:251-253.

       Wang XJ, Peng YJ, Li AN, Li DC. 2012 Directed evolution and structural prediction of cellobiohydrolase II from the thermophilic fungus Chaetomium thermophilum. Appl Microbiol Biotechnol 95:1469-1478.

       Li DC, Li AN, Papageorgiou AC. 2011. Cellulases from thermophilic fungi: Recent insights and biotechnological potential. Enzyme Research 2011(308730):1-9.

       Zhao PB, Ren AZ, Li DC. 2011. The FUS3/KSS1-type MAP kinase gene FPK1 is involved in hyphal growth, conidiation and plant infection of Fusarium proliferatum. J Mol Microbiol Biotechnol. 21:110-119.

       Xu HJ, Wang YJ, Zhao PB, Xu RY, Zhang YB, Li DC. 2011. A cAMP-dependent protein kinase gene, aapk1, is required for mycelia growth, toxicity and pathogenicity of Alternaria alternata on tobacco. Journal of Phytopathology 159: 208-216.

       Li AN, Xie C, Zhang J, Zhang J, Li DC. 2011. Cloning, expression and characterization of serine protease from thermophilic fungus Thermoascus aurantiacus var. levisporus. J Microbiol 49:121-129.

       Zheng YY, Guo XH, Song NN, Li DC. 2011. Thermophilic lipase from Thermomyces lanuginosus: gene cloning, expression and characterization. J Molecular Catalysis B Enzymatic 69:127-132.

       Xu RY, Teng FC, Zhang C, Li DC. 2011. Cloning of a gene encoding β-glucosidase from Chaetomium thermophilum CT2 and its expression in Pichia pastoris. J Mol Microbiol Biotechnol 20:16-23.

       Zhang LQ, Guo FX, Xian HQ, Wang XJ, Li AN, Li DC. 2011. Expression of a novel thermostable Cu, Zn-superoxide dismutase from Chaetomium thermophilum in Pichia pastoris and its antioxidant properties. Biotechnol Lett 33:1127-1132.

       Li AN, Yu K, Liu HQ, Zhang J, Li H, Li DC. 2010. Two novel thermostable chitinase genes from thermophilic fungi: cloning, expression and characterization. Bioresourse Technology, 101:5546-5551.

       Zhao PB, Ren AZ, Xu HJ, Li DC. 2010. The gene fpk1, encoding a cAMP-dependent protein kinase catalytic subunit homolog, is required for hyphal growth, spore germination, and plant infection in Fusarium verticillioides (Fusarium moniliforme). J Microbiol Biotechnol 20:208-216.

       Wakadkar S, Zhang LQ, Li DC, Haikarainen T, Dhavala P, Papageorgiou AC. 2010. Expression, purification and crystallization of Chaetomium thermophilum Cu,Zn superoxide dismutase. Acta Crystallogr Sect F Struct Biol Cryst Commun.66:1089-1092.

       Li YL, Li Hua, Li AN, and Li DC 2009 Cloning of cellulase gene (cbh3) of Chaetomium thermophilum and expression in Pichia pastoris. J Appl Microbiol106:1867-1875.

       Li AN, Li DC 2009 Cloning of protease gene of the thermophilic fungus Chaetomium thermophilum and expression in Pichia pastoris. J Appl Microbiol 106:369-380.

       Guo FX, E SJ, Liu SA, Chen J & Li DC 2008. Purification and characterization of a thermostable MnSOD from the thermophilic fungus Chaetomium thermophilum. Mycologia, 100: 375-380.

       Chen J, Zhou QX, Li DC 2007 Cloning of glucoamylase gene of Chaetomium thermophilum and expression in Pichia pastoris. J Appl Microbiol 103:2277-2284.

       Li AN, Ding AY, Chen J, Liu SA, Zhang M, Li DC. 2007. Purification and characterization of two thermostable proteases from the thermophilic fungus Chaetomium thermophilum. Appl Microbiol Biotechnol, 17:624-631.

    4、授权的发明专利

       李多川 陈静. 表达嗜热毛壳菌gla基因的酵母工程菌株及其构建方法(ZL200610043937.2

       李多川 李安娜 韩双. 表达疏绵状嗜热丝胞菌脂肪酶突变体的酵母工程菌株(ZL201310204916.4.

       李多川 韩超. 表达9家族糖苷水解酶基因CtAA9d的毕赤酵母工程菌株(ZL201310422852.5.

    5、科技奖励

       新型生物饲料添加剂产业化技术示范与推广,北京市科学技术奖二等奖(2014年, 6获奖人)

    6、出版著作

       Li DC. 2015. Cellulases from Thermophilic Fungi. In Thermophilic Microorganisms (Edited by FL Li). Caister Academic Press.

       Li DC, Li AN. 2009. Current Advances in Fungal Chitinases. In Applied Mycology (Edited by Rai M, Bridge PD). CABI.

    7、近期承担的科研项目

       生物质定向酶解关键技术(2015BAD15B05),国家支撑计划课题,2015-2018.

       嗜热真菌热稳定纤维素酶的分子改造及高活性新酶创制(2012AA10180402, 国家863计划课题,2012-2015.

       嗜热真菌热稳定耐甲醇脂肪酶创制及在微藻生物柴油转化中的利用(SDME2011SW01),国家海洋可再生能源专项资金项目,2011-2014.

       菌寄生过程中寄主真菌识别相关蛋白的基因克隆与功能研究(31071723),国家自然科学基金,2011-2013.

       联系方式

       通讯地址:山东省泰安市岱宗大街61

       邮编:271018

       联系电话:0538-8249071

       E-mail: lidc20@sdau.edu.cn