职    称

 教授

科研方向

 生物育种

招生专业

 植物保护（植物病理学）

联系方式

  wzhang@sdau.edu.cn

个人简介

张文正，男，汉族，中共党员，教授，博士生导师。2008年获得中国农业大学生物学院理学博士学位。在学术研究方面，以共同第一作者身份在Plant Cell，Plant Physiology，Nucleic Acid Research，Molecular Plant 等期刊发表文章，累计影响因子达60+。自2012年起，科研工作重心转向植物基因编辑育种研究。于2016年、2019年先后任职美国基因编辑育种公司Calyxt、 Inari。2019年在美国联合创立生物育种公司NeoGreenBio LLC。自2016年起，利用基因编辑育种技术在油菜、大豆、苜蓿等作物中创建相关育种平台，并开发多个新品种，包括全球首个投入商业应用的基因编辑苜蓿品种。

教学背景及工作经历

2025 – 至今山东农业大学植物保护学院，教授

2019 – 2025 共同创立NeoGreenBio LLC生物科技有限公司并担任公司经理

2019 – 2019 Inari公司，资深科学家、遗传转化部门总监

2016 – 2018 Calyxt公司，品种开发科学家、研发科学家、项目经理

2012 – 2016 The Samuel Roberts Noble Foundation，博士后

2008 – 2016 University of Colorado，博士后

2004 – 2008 中国农业大学生物学院植物生理生化国家重点实验室，博士

研究方向

1.基因编辑育种技术在作物抗病、抗虫新品种开发中的应用；

2.重要油料作物（大豆、油菜等）的生物育种；

3.重要牧草作物（苜蓿等）的生物育种。

代表性科研成果

I论文

Li X*, Zhang W*, Xu T, Ramsey J, Zhang L, Hill R, Hansen KC, Hesselberth JR, Zhao R. Comprehensive in vivo RNA-binding site analyses reveal a role of Prp8 in spliceosomal assembly. Nucleic Acids Res. 2013 Apr 1; 41(6):3805-18.

* Both authors contributed equally to the work.

Zhao LN*, Shen LK*, Zhang WZ*, Zhang W*, Wang Y, Wu WH. Ca²⁺-dependent protein kinase11 and 24 modulate the activity of the inward rectifying K⁺ channels in Arabidopsis pollen tubes. Plant Cell., 2013 Feb; 25(2):649-61.

* These authors contributed equally to the work.

Liu WX*, Zhang FC*, Zhang WZ*, Song LF, Wu WH, Chen YF. Arabidopsis Di19 functions as a transcription factor and modulates PR1, PR2 and PR5 expressions in response to drought stress. Mol Plant., 2013 Sep; 6(5):1487-502.

* These authors contributed equally to the work.

Wang Y*, Zhang WZ*, Song LF, Zou JJ, Su Z and Wu WH. Transcriptome analyses show changes in gene expression to accompany pollen germination and tube growth in Arabidopsis. Plant Physiol., 2008 Nov; 148(3):1201-11.

* Both authors contributed equally to the work.

II 专利授权

WO2020012365A1- CANOLA WITH HIGH OLEIC ACID, 发明人: Wenzheng Zhang, Feng zhang., International Publication Date: 2020 Jan 16.

其他科研成果

Park JJ, Dempewolf E, Zhang W, Wang ZY. RNA-guided transcriptional activation via CRISPR/dCas9 mimics overexpression phenotypes in Arabidopsis. PLOS One., 2017 Jun 16; 12(6):e0179410.

Chai M, Zhou C, Molina I, Fu C, Nakashima J, Li G, Zhang W, Park J, Tang Y, Jiang Q, Wang ZY. A class II KNOX gene, KNOX4, controls seed physical dormancy. Proc Natl Acad Sci U S A. 2016 Jun 21;113(25):6997-7002.

Zou JJ, Li XD, Ratnasekera D, Wang C, Liu WX, Song LF, Zhang WZ, Wu WH. Arabidopsis CALCIUM-DEPENDENT PROTEIN KINASE8 and CATALASE3 function in abscisic acid-mediated signaling and H2O2 homeostasis in stomatal guard cells under drought stress. Plant Cell., 2015 May; 27(5):1455-60.

Zhang L, Li X, Hill RC, Qiu Y, Zhang W, Hansen KC, Zhao R. Brr2 plays a role in spliceosomal activation in addition to U4/U6 unwinding. Nucleic Acids Res. 2015 Mar 31;43(6):3286-97.

Zhou C, Han L, Fu C, Chai M, Zhang W, Li G, Tang Y, Wang ZY. Identification and characterization of petiolule-like pulvinus mutants with abolished nyctinastic leaf movement in the model legume Medicago truncatula. New Phytol., 2012 Oct; 196(1):92-100.

Zou J, Song L, Zhang W, Wang Y, Ruan S, Wu WH. Comparative proteomic analysis of Arabidopsis mature pollen and germinated pollen. J Integr Plant Biol., 2009 May; 51(5):438-55.

Song LF, Zou JJ, Zhang WZ, Wu WH, Wang Y.Ion transporters involved in pollen germination and pollen tube tip-growth. Plant Signal Behav., 2009 Dec; 4(12):1193-5.

Wang YF, Fan LM, Zhang WZ, Zhang W, Wu WH. Ca²⁺-permeable channels in the plasma membrane of Arabidopsis pollen are regulated by actin microfilaments. Plant Physiol., 2004 Dec; 136(4):3892-904.